Leaky Gut Complete Test – Leaky gut syndrome – Verisana Lab
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Leaky Gut Complete

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With the Leaky Gut Complete Test, you receive an extensive examination of your intestine based on your stool sample:

1.) Candida and mold
2.) Bacterial imbalance of the intestinal flora
3.) pH-value of the stool
4.) Alpha-1-antitrypsin (inflammation)
5.) Secretory IgA (gut mucosal immunology)
6.) Zonulin value

In the leaky gut syndrome the intestinal mucosa becomes permeable – The immune system reacts with inflammatory and allergic processes.

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  • Details
  • Test measures
  • Symptoms
  • Sample collection guide
  • Sample report
  • Reviews
Details
Who should take the test?

The leaky gut syndrome affects in particular the small intestine, not the large one. But what does it mean when the small intestine is leaking?

The intestinal mucosa is a barrier between the intestinal contents and the blood circulation. When the barrier is intact, the intestinal mucosa allows only water and the necessary nutrients to pass into the bloodstream. In the leaky gut syndrome the intestinal mucosa becomes permeable – harmful substances pass unhindered into the bloodstream. The immune system reacts with inflammatory and allergic processes. Triggers may be an unhealthy diet, stress, infections as well as a frequent intake of antibiotics. Once recognized, the disease has good healing prospects.

The test Leaky Gut Complete Test combines our “Leaky Gut Test” and the “Zonulin Test”. The protein molecule zonulin is a suitable marker to measure the permeability of the intestinal mucosa. Zonulin regulates the exchange of fluid, macromolecules and leukocytes between bloodstream and intestinal lumen. High zonulin values can typically be observed in case of Diabetes Type 1, autoimmune diseases, celiac disease, multiple sclerosis, rheumatoid arthritis and other chronic diseases.

The test analyzes the values of the following analytes:

  • Escherichia coli
  • Proteus
  • Citrobacter
  • Klebsiella
  • Other enterobacteriaceae
  • Enterococci
  • Pseudomonas
  • Bacteroides
  • Bifidobacteria
  • Lactobacilli
  • Clostridia
  • pH-Value
  • Candida albicans
  • Candida spec.
  • Geotrichum candidum
  • Yeast
  • Alpha-1-Antitrypsin
  • Secretory IgA
  • Zonulin

Our Leaky Gut Complete Test gives you information about the condition of your intestinal mucosa as an impermeable gut is necessary for your general health and well-being.

How does it work?

You collect the samples at home, send them back to us and we will provide you with your level of each analyte and whether your level falls within the reference ranges for your age. In addition to that, the results include graphs showing whether your are in the “green” (=normal/healthy) or “red” (=too high/low) area, making it easy to understand the results.

What will my results tell me?

Your results will provide detailed information about whether your escherichia coli, proteus, citrobacter, klebsiella, other enterobacteriaceae, enterococci, pseudomonas, bacteroides, bifidobacteria, lactobacilli, clostridia, pH-Value, candida albicans, candida spec., geotrichum candidum, yeast, alpha-1-Antitrypsin, zonulin and secretory IgA levels are normal, low, or high compared to reference ranges in your age group. You can then discuss the results with your doctor or health practitioner, who can give you further guidance and treatment recommendations.

What guidance will I get along with my results?

We always recommend the discussion of the mailed results with your doctor or practitioner. Although we do not offer therapy service ourselves, we will gladly assist you in finding a suitable therapist in your area. Besides, further information is available on our website, especially in the different test categories, under “health conditions” and the FAQs. Still have questions? Then you can contact us by phone at (703) 722 6067 (08:00am – 11:30am EST) or mail at contact@verisana.com.

Test measures
For the Leaky Gut Complete Test we analyse:
  • Escherichia coli
  • Proteus
  • Citrobacter
  • Klebsiella
  • Other enterobacteriaceae
  • Enterococci
  • Pseudomonas
  • Bacteroides
  • Bifidobacteria
  • Lactobacilli
  • Clostridia
  • pH-Value
  • Candida albicans
  • Candida spec.
  • Geotrichum candidum
  • Yeast
  • Alpha-1-Antitrypsin
  • Secretory IgA
  • Zonulin
Escherichia coli

Escherichia coli (E. coli) is a minority member of the gut microbiome, but a very important one. E. coli bacteria normally live in the intestines of healthy people and stimulates the intestinal immune system. It aids digestion and protects us from other harmful microbes. E. coli ferments to produce folic acid, vitamin K2 (this protects against osteoporosis) and Co-enzyme Q10 (essential for mitochondrial function). If there are low counts of E-coli, one can expect problems like osteoporosis and bone problems, mitochondrial function, low mood and poor gut motility. Increased E. coli indicates putrefaction in the intestine and may burden the body with metabolic toxins. Potential causes may be reduced immunity of the intestinal mucosa, low counts of bifidobacteria or excess supply of protein.

Proteus

Proteus species are most commonly found as part of normal human intestinal flora, along with Escherichia coli and Klebsiella species. Proteus is also found in multiple environmental habitats, including long-term care facilities and hospitals. As a particularly active proteolytic germ, proteus can burden the body considerably through its metabolic toxins.

Citrobacter

Citrobacter is a rod belonging to the Enterobacteriaceae family. It is considered an opportunistic pathogen and therefore can be found in the gut as part of the normal flora. Citrobacter are also commonly found in water, soil and food and may be spread by person-to person contact.

Klebsiella

Klebsiella is a bacterium, which belongs to the Enterobacteriaceae family. Klebsiella can be found in the gastrointestinal tract of humans. Klebsiella overgrowth is commonly asymtomatic. Some strains of Klebsiella may cause diarrhea and some are enterotoxigenic. A low-starch diet may be helpful if high levels of Klebsiella are present.

Other enterobacteriaceae

Increased enterobacteriaceae indicate disturbances of the intestinal flora, malnutrition or digestive insufficiencies. A larger amount of these bacteria does not belong in the normal intestinal flora. Their multiplication often results from past antibioses.

Enterococci

Decreased Enterococci in the stool indicates disturbances in balance of the intestinal flora. Enterococci produce short-chain fatty acids during the carbohydrate utilisation, which contributes to the acidification and stabilisation of the intestinal environment. As an important contribution to the intestinal milieu, they produce bacteriostatic substances.

Pseudomonas

Pseudomonas can be found in water and soil as well as fruits ans vegetables. A common source of infection is bottled water, but increased Pseudonomas may also be due to an earlier antibiotic therapy.

Bacteroides

Bacteroides is the most abundant bacteria in the microflora, which allows us to digest soluble fibre and make short chain fatty acids. Decreased bacteroides indicate a lowered resistence to pathogenic species (such as salmonella, shigella and clostridia).

Bifidobacteria

Bifidobacteria make up a significant portion of the human gut flora. Along with Lactobacillia and Enterococci, Bifidobacteria control potentially pathogenic organisms and stimulate the intestinal immune system (GALT). Bifidobacteria metabolize carbohydrates only. By doing so, they produce short chain fatty acids, which adidify the intestine and couteract pathogenic organisms. Decreased Bifidobacteria indicate deficiencies in colonisation resistance, putrefaction in the intestine and can promote constipation.

Lactobacilli

Lactobacilli is a lactic acid forming bacteria, which produces large amounts of short chain fatty acids (SCFA). SCFAs lower the intestinal pH and thereby make the evironment alkaline and unsuitable for microbial pathogens (e.g. yeast). In addition, Lactobacilli secrete antifungal and antimicrobial agents. Decreased Lactobacilli indicate disturbances of the intestinal flora.

Clostridia

Clostridia are prevalent flora in a healthy intestine. As clostirida produce gases it may cause flatulence. Increased Clostridia indicates putrefaction in the intestine and may burden the body with metabolic toxins. Increased clostridia are often found in older people due to changes in their nutrition. Clostridium difficile and Clostridium perfringens are one cause of antibiotic-associated diarrhea.

pH-Value

Fecal pH is influenced by numerous factors, but is largely dependet on the fermentation of fiber by the beneficial flora of the gut. With a balanced diet the fecal pH should lie between 6,2 and 6,8. Acid fecal pH indicates disorders of intestinal ecology. An alkaline fecal pH indicated an imbalanced intestine flora. It is possible that proteolytic putrefactive germs are predominant, which raise the fecal pH through alkaline metabolites (e.g. due to a high-protein diet).

Candida albicans

The genus Candida is comprised of approximately 200 different species. Candida albicans is the most common strain of them. It is a normal part of the gut flora and most people have some level of Candida albicans in their intestines. But a combination of factors can lead to an overgrowth, which then leads to several undesirable symptoms including fatigue, weight gain, joint pain, and gas.

Candida spec.

Increased candida species indicates deficiancies in colonisation resitance, disturbances of the intestinal flora and or a defect mucosa. Candida species may burden the body with toxic metabolites. Some patients respont to even low rates of yeast overgrowth.

Geotrichum candidum

Geotrichum candidum belongs to the Endomyceteaceae family. This organism can be found in soil, dairy products and in human skin and mucosae. Symptoms of Geotrichum infection have been associated with diarrhea and enteritis.

Yeast

An infection with yeasts can have many reasons. Possible causes are things like corticosteroid therapy, stress, diabetes, malnutrition or birth control pills. All of them weaken the immune system and a weakened immune system cannot control yeast or help you get rid of it. Antibiotics are also a common cause of yeast infection because they destroy the good bacteria that keep it under control.

Alpha-1-Antitrypsin

Alpha-1-antitrypsin is a glycoprotein, which is produced by the liver and cells of the gut. It belongs to the group of acute phase proteins and is a marker of of protein loss and permeability of the gut.The measurement of Alpha-1-antitrypsin in stool reflects the permeability of the gut during inflammatory processes. Increased Alpha-1-antitrypsin indicates an increased permeability of the intestinal mucous membrane, which leads to an enteral loss of Alpha-1-antitrypsin.

Secretory IgA

Secretory IgA (sIgA) is an immune protein, which reacts anti-inflammatory. It coats the intestinal lining, especially the mucosal surfaces and is supposed to protect us from inside. As secretory IgA represents the first line of defense of the GI, immunological activity in the GI tract can be assessed using secretory IgA. Low levels of fecal sIgA increase the risk of leaky gut syndrome and promote the growth of microbial pathogens in the intestine. The risk of inflammatroy immune reactions to undigested food and protein is also increased if low levels of sIgA are present. Low fecal IgA levels can result from physical or mental stress and/or inadequate nutrition. High fecal sIgA indicate immune reactions to antigens from bacteria, yeast or other microbes.

Zonulin

Zonulin is a protein molecule that helps with the regulation of tight junctions in your intestinal wall. When it connects to specific receptors on the cell surface, the tight junctions open up and therefore increase your intestinal permeability. This can be caused e.g. by being exposed to certain types of bacteria. The ensuing exposure to foreign antigens and cell components can cause immunological reactions and dysregulations. High Zonulin values can typically be observed in case of Diabetes Type 1, autoimmune diseases, celiac disease, multiple sclerosis, rheumatoid arthritis and other chronic diseases.

Symptoms
Symptoms the Leaky Gut Complete Test is suitable for:
  • Swollen stomach
  • Flatulence
  • Constipation
  • Food intolerance
  • Migraine
  • Fatigue
  • Sleeping disorders
  • Concentration difficulties
  • Chronic joint pain
  • Chronic muscle pain
Sample collection guide
General

Please read the following instructions in detail, before starting with the sample collection.

 

Please download the instructions here

Sample report
The sample report

Below you will find the sample report for the Leaky Gut Complete Test.

Download sample report

aaBewertungen
Comments
  1. Caren T.
    March 11, 2019

    I suffered from food intolerances which got worse and worse. Over time, there wasn’t a lot left that I could eat. No one could tell me the cause, until my naturopath suggested it might be a leaky gut. I would never have thought of this, since I don’t havee any other symptoms. But the intolerances really vanished after my treatment and I can eat almost everything now! I do keep on a special diet though to prevent the leaky gut from coming back.

  2. Sams NYC
    February 28, 2019

    Everything went fast and smooth. AND Verisana helped me find a naturopathic doctor. Changed my diet and started treatment after the test and I slowly start feeling better (no more constipation, YAY!).

  3. Richard S.
    February 14, 2019

    A lot of people come to me with a diffuse set of health problems, ranging from constipation and diarrhea to chronic fatigue and migraine. In these cases, it is crucial for me to be able to run reliable diagnostic tests such as this that help to determine the root causes – which can incresingly be traced to a leaky gut, indeed

  4. Penny
    February 11, 2019

    Did the test 2 times and I’m very happy with everything. The 2nd test was to check whether the values got better (5 months after the first test). Results showed an enormous improvement and I sure feel better too.

  5. Lennart C.
    March 8, 2018

    I have been suffering from bad constipation and an increasing number of food intolerances for years. After many failed therapy attempls, I finally found this test, which confirmed that I indeed suffered from a leaky gut. It helped me a lot as I changed myy diet and add certain supplements that very much improved my condition.

  6. Kaz Watatani
    February 14, 2018

    Definitely worth the money.

Only logged in customers who have purchased this product may leave a review.

Any Questions?

Here are some of the most frequently asked questions regarding this test. Your question is missing? Please contact us at:

What does ""Leaky Gut"" mean?

"Leaky Gut" means "permeable intestine". The intestinal mucosa forms a natural barrier. It absorbs nutrients from food, but keeps harmful substances away. If the intestinal mucosa is damaged, it can no longer perform this task. In addition nutrients, toxins, metabolic products, etc. enter directly into the organism and can cause various kinds of complaints.

How does a "Leaky Gut" syndrome develop?

Possible causes include taking antibiotics or cortisone, pathogens (e.g. fungi and viruses), an unbalanced diet (too much sugar, white carbohydrates, soft drinks), chemotherapy or heavy metals.

What is the difference to the leaky gut test?

The "Leaky Gut Complete" test combines the leaky gut test and the zonulin test. Zonulin is a protein molecule that is involved in the regulation of intercellular contacts (tight junctions) in the intestinal wall. With its help, the tight junctions open and as a result increase the permeability of the intestinal mucosa. The combination of both tests gives a particularly comprehensive picture of the mucous membrane.

Why can a leaky gut cause joint pain?

Among other things, the inflammatory values ​​of the Leaky Gut Syndrome are increased. However, this is not only limited to the intestine, but can also show in other parts of the body. Joints are a particularly sensitive area for inflammation and are therefore more often affected than other parts of the body.

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